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2019 2
2020 2
2021 7
2022 1
2024 0

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Page 1
Biological evaluation and synthesis of calcitroic acid.
Yu OB, Webb DA, Di Milo ES, Mutchie TR, Teske KA, Chen T, Lin W, Peluso-Iltis C, Rochel N, Helmstädter M, Merk D, Arnold LA. Yu OB, et al. Among authors: helmstadter m. Bioorg Chem. 2021 Nov;116:105310. doi: 10.1016/j.bioorg.2021.105310. Epub 2021 Aug 28. Bioorg Chem. 2021. PMID: 34482171 Free PMC article. Review.
A New FXR Ligand Chemotype with Agonist/Antagonist Switch.
Helmstädter M, Vietor J, Sommer J, Schierle S, Willems S, Kaiser A, Schmidt J, Merk D. Helmstädter M, et al. ACS Med Chem Lett. 2021 Feb 1;12(2):267-274. doi: 10.1021/acsmedchemlett.0c00647. eCollection 2021 Feb 11. ACS Med Chem Lett. 2021. PMID: 33603974 Free PMC article.
Development and in vitro Profiling of Dual FXR/LTA4H Modulators.
Schierle S, Brunst S, Helmstädter M, Ebert R, Kramer JS, Steinhilber D, Proschak E, Merk D. Schierle S, et al. Among authors: helmstadter m. ChemMedChem. 2021 Aug 5;16(15):2366-2374. doi: 10.1002/cmdc.202100118. Epub 2021 May 24. ChemMedChem. 2021. PMID: 33856122 Free PMC article.
Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast.
Schierle S, Helmstädter M, Schmidt J, Hartmann M, Horz M, Kaiser A, Weizel L, Heitel P, Proschak A, Hernandez-Olmos V, Proschak E, Merk D. Schierle S, et al. Among authors: helmstadter m. ChemMedChem. 2020 Jan 7;15(1):50-67. doi: 10.1002/cmdc.201900576. Epub 2019 Nov 19. ChemMedChem. 2020. PMID: 31670489 Free PMC article.
Structure optimization of a new class of PPARγ antagonists.
Hernandez-Olmos V, Knape T, Heering J, von Knethen A, Kilu W, Kaiser A, Wurglics M, Helmstädter M, Merk D, Schubert-Zsilavecz M, Parnham MJ, Steinhilber D, Proschak E. Hernandez-Olmos V, et al. Among authors: helmstadter m. Bioorg Med Chem. 2019 Nov 1;27(21):115082. doi: 10.1016/j.bmc.2019.115082. Epub 2019 Aug 27. Bioorg Med Chem. 2019. PMID: 31548084
Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors.
Lillich FF, Willems S, Ni X, Kilu W, Borkowsky C, Brodsky M, Kramer JS, Brunst S, Hernandez-Olmos V, Heering J, Schierle S, Kestner RI, Mayser FM, Helmstädter M, Göbel T, Weizel L, Namgaladze D, Kaiser A, Steinhilber D, Pfeilschifter W, Kahnt AS, Proschak A, Chaikuad A, Knapp S, Merk D, Proschak E. Lillich FF, et al. Among authors: helmstadter m. J Med Chem. 2021 Dec 9;64(23):17259-17276. doi: 10.1021/acs.jmedchem.1c01331. Epub 2021 Nov 24. J Med Chem. 2021. PMID: 34818007
11 results